UConn AgingNet Faculty
George Kuchel, M.D., F.R.C.P.
Academic Title
Professor of Medicine
Citicorp Chair in Geriatrics and Gerontology
Director, UConn Center on Aging
Chief, Division of Geriatric Medicine
Education
McGill University (MD CM) 1980
Training
McGill University, Montreal General Hospital, Internal Medicine 1982-1985
Harvard Medical School, Geriatric Medicine 1985-1988
Research Interests
1. Pathophysiology of common geriatrics syndromes
2. Role of inflammatory molecules in mediating the loss of muscle and neural elements shown to contribute to detrusor underactivity and sarcopenia in frail older adults
3. Design and validation of pleiotropic and targeted interventions capable of altering the natural history of common geriatrics syndromes.
Areas of Special Clinical Interest
Geriatric Assessment, Urinary Incontinence
Languages Spoken
French, Czech, Slovak, Hungarian
Selected Publications
Kuchel G.A.(2009) Allostatic Load, Frailty and the Future of Predictive Gerontology. Journal of the American Geriatrics Society 57(9):1704-1706.
Jacquin C., Koczon-Jaremko B., Leng L., Bucala R., Kuchel G.A. and Lee S-K. (2009) Macrophage migration inhibitory factor (MIF) is an inhibitor of osteoclastogenesis in vitro and in vivo. Bone 45(4):640-9
DuBeau C.E., Kuchel G.A., Johnson T., Palmer M.H. and Wagg A. (2009) Incontinence in Frail Elderly. Neurourology and Urodynamics 18;29(1):165-178.
Wakefield D.B., Moscufo N., Guttmann C.R., Kuchel G.A., Kaplan R.F. and Wolfson L. (2010) White Matter Hyperintensities Predict Functional Decline in Voiding, Mobility and Cognition in Older Persons. Journal of the American Geriatrics Society 58:275-281.
Duque G. And Kuchel G.A.* (2010) Moving Beyond Static Body Composition Paradigms to Assessments of Change, Plasticity and Function. Journal of the American Geriatrics Society 58:377-379.
Smith, P.P. and Kuchel G.A. (2010) Continuous Uroflow Cystometry in the Urethane- Anesthetized Mouse. Neurourology and Urodynamics (In Press)
Deschênes M.C., Descovich D., Moreau M., Granger L., Kuchel G.A., Mikkola T.S., Fick G.H., Chemtob S, Vaucher E. and Lesk M.R.. (2009) Postmenopausal Hormone Therapy Increases Retinal Blood Flow and Protects the Retinal Nerve Fiber Layer Investigative Ophthalmology and Visual Science. (In Press)
Ma X.M., Huang J.P., Kim E.J., Zhu Q., Kuchel G.A., Mains R.E and Eipper B.A. (2010) Kalirin-7, an important component of excitatory synapses, is regulated by estrogen in hippocampal neurons. Hippocampus (In Press)
Taylor J.A., and Kuchel G.A.. (2006). Detrusor Underactivity: Clinical Features and Pathogenesis of an Underdiagnosed Geriatric Condition. Journal of the American Geriatrics Society 54 (12) 1920-1932.
Taylor J.A., Zhu Q., Irwin B., Maghayadah Y., Tsimikas J., Pilbeam C., Leng L., Bucala R. and Kuchel G.A. (2006) Null mutation in macrophage migration inhibitory factor (MIF) prevents muscle cell loss and fibrosis in partial bladder outlet obstruction. American Journal of Physiology - Renal Physiology 291 (6) F1343-1353.
Taylor J.A., Kuchel G.A., Hegde P., Voznesensky O.S., Claffey K., Tsimikas J., Leng L., Bucala R and Pilbeam C. (2007) Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice. BMC Cancer 7(1)135-142.
Pefanco M.A., Kenny, A., Kaplan R, Kuchel G.A., Walsh S., Kleppinger A. and Prestwood K. (2007) The Effect of 3-year treatment with 0.25 mg/d of Micronized 17β-Estradiol on Cognitive Function in Older Postmenopausal Women. Journal of the American Geriatrics Society 55 (3) 426-431.
Inouye S.K., Studenski S., Tinetti M.E. and Kuchel G.A. (2007) Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. Journal of the American Geriatrics Society 55(5) 780-791 (with accompanying editorial by W.B. Hazzard, MD 55(5) 794-796)
Estrada M., Kleppinger A., Judge J.O., Walsh S.J and Kuchel G.A.(2007) Functional Impact of Relative Versus Absolute Sarcopenia in Healthy Older Women. Journal of the American Geriatrics Society 55(11)1712-1719.
Rudolph J.L., Ramlawi B., Kuchel G.A., McElhaney J.E., Xie D., Selke F.W., Levkoff S.E. and Marcantonio E.R. (2008) Chemokines are Associated with Delirium after Cardiac Surgery. Journal of Gerontology: Medical Sciences 63(2):184-9
Leng S.X., McElhaney J.E., Walston J.D., Xie D., Fedarko N.S. and Kuchel G.A. (2008) ELISA and Multiplex Technologies for Cytokine Measurement in Inflammation and Aging Research. Journal of Gerontology: Medical Sciences (In Press)
Kuchel G.A. (2008) Using Caveolin-1 Knockout Mouse to Study Impaired Detrusor Contractility and Disrupted Muscarinic Activity in the Aging Bladder. Urology (In Press)
Plotnikov SV, Kenny A, Walsh SJ, Zubrowski B, Joseph C, Scranton VL. Kuchel GA., Dauser D, Xu M, Pilbeam C, Adams D, Dougherty R, Campagnola PJ and Mohler W.A. (2008) Measurement of muscle disease by quantitative second-harmonic generation imaging. Journal of Biomedical Optics (In Press)
Taylor J.A., Ristau B., Bonnemaison M., Voznesensky O.S., Hegde P., Kuchel G.A. and Pilbeam C.C. (2009) Regulation of the Prostaglandin Pathway during Development of Invasive Bladder Cancer in Mice. Prostaglandins and Other Lipid Mediators 88: 36-41.
Taylor J.A. and Kuchel G.A. (2009) The Clinical and Research Implications of Bladder Cancer in the Elderly. Nature (Clinical Practice Urology) 6.
Kuchel G.A., Moscufo N., Guttmann C., Zeevi N., Wakefield D., Schmidt J., DuBeau C. and Wolfson L. (2009) Localization of Brain White Matter Hyperintensities and Urinary Incontinence in Community-Dwelling Older Adults. Journal of Gerontology: Medical Sciences (In Press)
Chapters
Aviv A., Gardner S., Kuchel G.A., Kummerfeld S., Love C.L., Vlassara H., White M. and Colins A. (2008) Inflammation’s Effects on Aging IN The Future of the Human Healthspan. Demography, Evolution, Medicine and Bioengineering. Task Group Summaries. The National Academies. Keck Futures Initiative. The National Academies Press. Washington, DC.
Kuchel G.A.. (2009) Aging and Homeostatic Regulation. Ch. 51. IN Hazzard’s Principles of Geriatric Medicine and Gerontology. (Eds. Halter J.B., Hazzard W., Ouslander J.G., Tinetti M., Woolard N., Studenski S., High K. and Asthana S.) 6th edition. McGraw-Hill, New York, NY.
Kuchel G.A. (2008) Question Contributor for Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine. 7th Ed. New York, NY: American Geriatrics Society. (In Press)
Smith P.P. and Kuchel G.A. (2009) Aging of the Urinary Tract. Chapter 18 IN Brocklehurst's Textbook of Geriatric Medicine and Gerontology. 7th edition. Elsevier, Philadelphia, PA (In Press)
DuBeau C.E., Harari D., Johnson T., Kuchel G.A., Palmer M., Pfisterer M. and Wagg A. Incontinence in The Frail Elderly. IN Incontinence. 4th International Consultation on Incontinence. July 4-7, 2008. Editions 21, Paris, France (In Press)
Current Grants
R01 AG028657; Role PI; 4/1/2007-3/31/2012
NIH/NIA; Pathogenesis of detrusor underactivity and urinary retention in the frail elderly.
$1,517,000
R01 AR54713; Role co-PI (PI: DW Rowe) 7/1/2006-6/30/2011
NIH/NIAMS. Assessing Lineage Decisions of Musculoskeletal Progenitor Cells with Aging
$1,953,600
R01 AI068265; Role co-PI (PI: JE McElhaney) 4/1/2005-3/31/2010
NIH/NIAID. T-Cell Responses Predict Influenza Risk in Older Adults
$2,093,690
American Geriatrics Society; Role co-PI with K Parham 7/1/2007-6/30/2009
Geriatrics for Specialists Award
$40,000
Research Staff
Dan Sasso, B.Sc.
Qing Zhu, M.D., M.Sc.
Educational Contribution
Students (MD)
Fellows (MD)
Residents (MD)
CME
Contact Information
Phone: 860-679-3956
Fax: 860-679-1307 Personal Links
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