George Kuchel, M.D., F.R.C.P.
Professor of Medicine
Citicorp Chair in Geriatrics and Gerontology
Director, UConn Center on Aging
Chief, Division of Geriatric Medicine
McGill University (MD CM) 1980
McGill University, Montreal General Hospital, Internal Medicine 1982-1985
Harvard Medical School, Geriatric Medicine 1985-1988
1. Pathophysiology of common geriatrics syndromes
2. Role of inflammatory molecules in mediating the loss of muscle and neural elements shown to contribute to detrusor underactivity and sarcopenia in frail older adults
3. Design and validation of pleiotropic and targeted interventions capable of altering the natural history of common geriatrics syndromes.
Areas of Special Clinical Interest
Geriatric Assessment, Urinary Incontinence
French, Czech, Slovak, Hungarian
Smith P.P. and Kuchel G.A. (2013) Editorial Comment on Liao C.H. and Kuo H.C.Increased Risk of Large Post-Void Residual Urine and Lower Long-Term Success Rate in Frail Elderly Patients After Intravesical Onabotulinumtoxin A Injection for Refractory Idiopathic Detrusor Overactivity. The Journal of Urology. 189(5): 1810. PMID:23398719
Kositsawat J, Barry L.C. and Kuchel G.A. (2013) C-Reactive Protein, Vitamin D Deficiency and Slow Gait Speed. Journal of the American Geriatrics Society 61(9): 1574-1579. PMID: 23927858
Phipps M.S., Zeevi N., Staff I., Fortunato G., Kuchel, G.A. and McCullough L.D (2013) Stroke Severity and Outcomes for Octogenarians Receiving Statins. Archives of Gerontology and Geriatrics 57(3): 377-382. PMID: 23815970
Wakefield D.B., Moscufo N., Guttmann C.R., Kuchel G.A., Kaplan R.F. and Wolfson L. (2010) White Matter Hyperintensities Predict Functional Decline in Voiding, Mobility and Cognition in Older Persons. Journal of the American Geriatrics Society 58:275-281.
Duque G. And Kuchel G.A. (2010) Moving Beyond Static Body Composition Paradigms to Assessments of Change, Plasticity and Function. Journal of the American Geriatrics Society 58:377-379.
Smith, P.P. and Kuchel G.A. (2010) Continuous Uroflow Cystometry in the Urethane- Anesthetized Mouse. Neurourology and Urodynamics 29(7):1344-9.
Deschênes M.C., Descovich D., Moreau M., Granger L., Kuchel G.A., Mikkola T.S., Fick G.H., Chemtob S, Vaucher E. and Lesk M.R.. (2010) Postmenopausal Hormone Therapy Increases Retinal Blood Flow and Protects the Retinal Nerve Fiber Layer Investigative Ophthalmology and Visual Science. 51(5):2587-2600.
Zeevi N., Pachter J., McCullough L., Wolfson L. and Kuchel G.A. (2010) The Blood-Brain Barrier: Geriatric Relevance of a Critical Brain-Body Interface. Journal of the American Geriatrics Society 58: 1749-1757.
Ma X.M., Huang J.P., Kim E.J., Zhu Q., Kuchel G.A., Mains R.E and Eipper B.A. (2011) Kalirin-7, an important component of excitatory synapses, is regulated by estrogen in hippocampal neurons. Hippocampus Jun;21(6):661-77 doi: 10.1002/hipo.20780.
Swanberg M., McGuigan F., Ivaska K.K.,Gerdhem P., Lerner U.H., Bucala R., Kuchel G.A., Joseph C., Kenny A. and Akesson K. (2010) Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women. Bone Aug;47(2):424-9.
Zhou X., Fragala M.S., McElhaney J.E. and Kuchel G.A. (2010) Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research. Current Opinion on Clinical Nutrition and Metabolism. 13(5): 541-547.
Taillefer M.S., Tangarorang G.L., Kuchel G.A. and Menkes D.L. (2011) Atypical presentation of Creutzfeld-Jakob Disease, a rare but important cause of rapidly progressive dementia. Connecticut Medicine 75(8) 473-478.
Smith P.P., Wolfson L. and Kuchel G.A. (2011) The Neurourology of Urinary Symptoms in Older Adults. BJU International Online Edition DOI: 10.1002/BJUIw-2011-010-web at bjui.org 23/3/2011.
Zeevi N., Kuchel G.A., Lee N.S., Staff I. and McCullough L.D. Interventional Stroke Therapies in the Elderly. Are we helping? (2012) American Journal of Neuroradiology 33(4):638-42. Epub 2011 Nov 24.
Schmitt E.M., Marcantonio E.R., Alsop D.C., Jones R.N., Rogers S.O., Fong T.G., Metzger E., Inouye S.K. and the SAGES Study Group*. Novel risk markers and long-term outcomes of delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods. J Am Med Dir Assoc. 2012: In Press [*(George A Kuchel) is part of the SAGES Study Group]
Fragala M.M., Walsh S.J., Kleppinger A., Judge J.O., Kuchel G.A. and Kenny A.M. Gender Differences in Anthropometric Predictors of Physical Performance in Older Adults. Gender Medicine (In Press)
Smith P.P., DeAngelis A. and Kuchel G.A. (2012) Evidence of Central Modulation of Bladder Compliance during Filling.(2012) Neurourology and Urodynamics Jan;31(1):30-5.
Smith P.P., DeAngelis A. and Kuchel G.A. Detrusor Expulsive Strength is Preserved, but Responsiveness to Bladder Filling and Urinary Sensitivity Diminished in the Aging Mouse. (2012) American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. Mar 1;302(5):R577-86.
Kuchel G.A.. (2009) Aging and Homeostatic Regulation. Ch. 51, Pgs. 621-630. IN Hazzard’s Principles of Geriatric Medicine and Gerontology. (Eds. Halter J.B., Hazzard W., Ouslander J.G., Tinetti M., Woolard N., Studenski S., High K. and Asthana S.) 6th edition. McGraw-Hill, New York, NY.
Aviv A., Gardner S., Kuchel G.A., Kummerfeld S., Love C.L., Vlassara H., White M. and Colins A. (2008) Inflammation’s Effects on Aging IN The Future of the Human Healthspan. Demography, Evolution, Medicine and Bioengineering. Task Group Summaries. The National Academies. Keck Futures Initiative. The National Academies Press. Washington, DC.
DuBeau C.E., Harari D., Johnson T., Kuchel G.A., Palmer M., Pfisterer M. and Wagg A. (2008) Incontinence in The Frail Elderly. IN Incontinence. 4th International Consultation on Incontinence. July 4-7, 2008. Editions 21, Paris, France
Kuchel G.A. and DuBeau C.E..(2009) Urinary Incontinence in the Elderly. Ch. 27. IN Geriatric Nephrology Curriculum. (Eds. Kohan D. and Oreopoulos D.), American Society of Nephrology
Smith P.P. and Kuchel G.A. (2010) Aging of the Urinary Tract. Ch.18, Pgs. 111-116. IN Brocklehurst's Textbook of Geriatric Medicine and Gerontology. (Eds. Fillit H.M., Rockwood K. and Woodhouse K.) 7th edition. Elsevier, Philadelphia, PA.
Kuchel G.A. (2010) Question Contributor for Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine. Pacala JT, Sullivan GM, eds. 7th Ed. New York, NY: American Geriatrics Society.
Kuchel G.A. (2010) Aging versus Disease. Ch.2, Pgs. 8-13 IN Cutting Edge. Ageing and the Lower Urinary Tract. Astellas Pharma, A/S Denmark.
Kuchel G.A. (2011) Question Contributor for Geriatrics Nursing Review Syllabus: A Core Curriculum in Advanced Practice Geriatric Nursing. Flaherty E, Resnick B. eds. 3rd Ed. New York, NY: American Geriatrics Society.
DeAngelis A., Smith P.P. and Kuchel G.A. (2012) MIF and Lower Urinary Tract Disorders. Chapter III-5, Pgs. 257-275 IN The MIF Handbook. (Ed. Bucala R.) World Scientific Publishing, Hackensack, NJ.
Kuchel G.A., Robison J. and Fortinsky R. (2012) Physiological, Psychological and Social Aspects of Aging. Ch. 3, Pgs. 35-51 IN Cancer and Aging handbook: Research and Practice. (Eds. Bellizzi K. and Gosney M.), Wiley-Blackwell, Hoboken, NJ.
CICATS 2013 SIG Grant Program Kuchel (PI) 12/01/13-12/31/14
CT Inst. for Clinical & Translational Science $29,941
Translating Gait Velocity Measurements into Real World Clinical Settings
The goal of this project is to construct a prototype device for the unobtrusive measurement of gait velocity in typical clinical settings.
Role: Principal Investigator
12-SCA-UCHC-15 Kuchel (PI) 03/01/13-02/28/15
Connecticut Innovations Stem Cell Grant
Embryonic and pluripotent stem cell-produced factors as novel therapeutic candidates for improving muscle function and regenerative responses in humans
The goal of the project is to define pro-regenerative factors produced by embryonic & induced pluripotent stem cells which positively regulate the behavior of young and old muscle stem (satellite) cells, offering potential for “youthful” reprogramming of aged stem cells and for interventions targeting sarcopenia & functional declines in old age.
Role: Role: PI
P01 AG031720 Inouye (PI) 04/15/10-03/31/15
Harvard Interdisciplinary Study of Delirium and Its Long-Term Outcomes - Biomarker Discovery for Delirium
This subproject will integrate biomarker discovery of inflammatory markers into a program project which will enroll a prospective cohort of 500 older patients undergoing scheduled non-cardiac surgery. The goal of this study is to discern biomarker signatures for delirium.
U13AG039151 Kuchel (PI) 07/01/03-05/31/15
Conference Series in Geriatrics: From Bedside to Bench
The goal of this U13 Conference Grant is to fund a series of three annual conferences addressing new research approaches into Delirium, Sleep Disorders and Urinary Incontinence.
R01AG022092 White/Wolfson (Co-PIs) 07/01/03 – 05/31/16
Intensive Blood Pressure Reduction to Lessen Functional Decline
The goal of this project is to assess causality between 24-h systolic BP and reductions in mobility, associated with WMH in older people. The study will determine the impact of reducing the 24-h systolic BP to a goal of <125 mmHg (intensive BP control) vs. a goal of <140 mmHg (standard BP control).
CCF-1331850 Pattipati (PI) 10/01/13-09/30/16
National Science Foundation
CyberSEES: Type 2: Fault Detection, Diagnosis and Prognosis of HVAC Systems
Dr. Kuchel’s responsibility on this subproject is for survey development and administration to support the targeted implementation of Energy Smart Building technology by UConn School of Engineering investigators at Duncaster, a Continuing Care Retirement Community (CCRC).
7P01AG021600 Haynes (PI) 12/02/02-05/31/17
Aging and Immunity to Infection
The goal of this project is to understand how aging affects the immune system and the capacity of older adults to respond to influenza vaccine. The focus of the studies conducted at UCHC will be elucidate the nature of the defects in the generation of effector and memory functions in aged naïve CD4+ T cells and determine their potential reversibility in cells from older adults using vaccines and adjuvants.
Role: Co-Investigator and Project Leader (Project 4)
1 UD7HP268980100 Malcolm (PI) 07/01/14-06/30/17
Geriatric Outreach in Training Program
The Center on Aging will assist in the development of an IPCP curriculum and course in the content area of geriatrics as related to Public Health; provide students from the Graduate School, Public Health Program to participate in a faculty lead IPCP geriatric education program; participate in the GOT Care! Program according to the scope of Public Health, and participate in analysis of the outcome measures for the program to inform modifications for the next cycle of the program during each academic semester.
1R01AG048023 Kuchel (PI) 07/15/14-05/31/19
Immune Response to High-Dose vs. Standard Dose Influenza Vaccine
This project is a randomized study of split-virus influenza vaccine (SVV) in a high-dose (HD) vs. standard dose (SD) formulation in each of five influenza seasons to define the key determinants of vaccine-mediated protection against influenza and how these immunologic mediators may be enhanced by vaccination with a newly approved high-dose influenza vaccine in frail older subjects.
Role: Principal Investigator
Xin Zhou, PhD
Qing Zhu, M.D., M.Sc.