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George Kuchel, M.D., F.R.C.P.photo of george kuchel, m.d., f.r.c.p.

Academic Title
Professor of Medicine
Citicorp Chair in Geriatrics and Gerontology
Director, UConn Center on Aging
Chief, Division of Geriatric Medicine

Education
McGill University (MD CM) 1980

Training
McGill University, Montreal General Hospital, Internal Medicine 1982-1985
Harvard Medical School, Geriatric Medicine 1985-1988

Research Interests
1.        Pathophysiology of common geriatrics syndromes
2.        Role of inflammatory molecules in mediating the loss of muscle and neural elements shown to contribute to detrusor underactivity and sarcopenia in frail older adults
3.        Design and validation of pleiotropic and targeted interventions capable of altering the natural history of common geriatrics syndromes.

Areas of Special Clinical Interest
Geriatric Assessment, Urinary Incontinence

Languages Spoken
French, Czech, Slovak, Hungarian

Recent Publications

Smith P.P. and Kuchel G.A. (2013) Editorial Comment on Liao C.H. and Kuo H.C.Increased Risk of Large Post-Void Residual Urine and Lower Long-Term Success Rate in Frail Elderly Patients After Intravesical Onabotulinumtoxin A Injection for Refractory Idiopathic Detrusor Overactivity. The Journal of Urology. 189(5): 1810. PMID:23398719

Kositsawat J, Barry L.C. and Kuchel G.A. (2013) C-Reactive Protein, Vitamin D Deficiency and Slow Gait Speed.  Journal of the American Geriatrics Society 61(9): 1574-1579. PMID: 23927858

Phipps M.S., Zeevi N., Staff I., Fortunato G., Kuchel, G.A. and McCullough L.D (2013) Stroke Severity and Outcomes for Octogenarians Receiving Statins. Archives of Gerontology and Geriatrics  57(3): 377-382. PMID: 23815970

Wakefield D.B., Moscufo N., Guttmann C.R., Kuchel G.A., Kaplan R.F. and Wolfson L. (2010) White Matter Hyperintensities Predict Functional Decline in Voiding, Mobility and Cognition in Older Persons.  Journal of the American Geriatrics Society  58:275-281.

Duque G. And Kuchel G.A. (2010) Moving Beyond Static Body Composition Paradigms to Assessments of Change, Plasticity and Function. Journal of the American Geriatrics Society  58:377-379.

Smith, P.P. and Kuchel G.A. (2010) Continuous Uroflow Cystometry in the Urethane- Anesthetized Mouse. Neurourology and Urodynamics 29(7):1344-9.

Deschênes M.C., Descovich D., Moreau M., Granger L., Kuchel G.A., Mikkola T.S., Fick G.H., Chemtob S, Vaucher E. and Lesk M.R.. (2010)  Postmenopausal Hormone Therapy Increases  Retinal Blood Flow and Protects the Retinal Nerve Fiber Layer Investigative Ophthalmology and Visual Science. 51(5):2587-2600.

Zeevi N., Pachter J., McCullough L., Wolfson L. and Kuchel G.A. (2010) The Blood-Brain Barrier: Geriatric Relevance of a Critical Brain-Body Interface. Journal of the American Geriatrics Society  58: 1749-1757.

Ma X.M., Huang J.P., Kim E.J., Zhu Q., Kuchel G.A., Mains R.E and Eipper B.A. (2011) Kalirin-7, an important component of excitatory synapses, is regulated by estrogen in hippocampal neurons. Hippocampus Jun;21(6):661-77  doi: 10.1002/hipo.20780.

Swanberg M., McGuigan F., Ivaska K.K.,Gerdhem P., Lerner U.H., Bucala R., Kuchel G.A., Joseph C., Kenny A. and Akesson K. (2010) Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women. Bone  Aug;47(2):424-9.

Zhou X., Fragala M.S., McElhaney J.E. and Kuchel G.A. (2010) Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research. Current Opinion on Clinical Nutrition and Metabolism. 13(5): 541-547.

Taillefer M.S., Tangarorang G.L., Kuchel G.A.  and Menkes D.L. (2011) Atypical presentation of Creutzfeld-Jakob Disease, a rare but important cause of rapidly progressive dementia. Connecticut Medicine 75(8) 473-478.

Smith P.P., Wolfson L. and Kuchel G.A. (2011) The Neurourology of Urinary Symptoms in Older Adults. BJU International Online Edition DOI: 10.1002/BJUIw-2011-010-web at bjui.org 23/3/2011.

Zeevi N., Kuchel G.A., Lee N.S., Staff I. and McCullough L.D. Interventional Stroke Therapies in the Elderly. Are we helping? (2012) American Journal of Neuroradiology 33(4):638-42. Epub 2011 Nov 24.

Schmitt E.M., Marcantonio E.R., Alsop D.C., Jones R.N., Rogers S.O., Fong T.G., Metzger E., Inouye S.K. and the SAGES Study Group*. Novel risk markers and long-term outcomes of delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods. J Am Med Dir Assoc. 2012: In Press [*(George A Kuchel) is part of the SAGES Study Group]

Fragala M.M., Walsh S.J., Kleppinger A., Judge J.O., Kuchel G.A. and Kenny A.M. Gender Differences in Anthropometric Predictors of Physical Performance in Older Adults. Gender Medicine (In Press)

Smith P.P., DeAngelis A. and Kuchel G.A. (2012) Evidence of Central Modulation of Bladder Compliance during Filling.(2012) Neurourology and Urodynamics Jan;31(1):30-5.

Smith P.P., DeAngelis A. and Kuchel G.A.  Detrusor Expulsive Strength is Preserved, but Responsiveness to Bladder Filling and Urinary Sensitivity Diminished in the Aging Mouse. (2012) American Journal of Physiology – Regulatory, Integrative and Comparative Physiology. Mar 1;302(5):R577-86.

Recent Chapters
Kuchel G.A.. (2009) Aging and Homeostatic Regulation. Ch. 51, Pgs. 621-630. IN Hazzard’s Principles of Geriatric Medicine and Gerontology. (Eds. Halter J.B., Hazzard W., Ouslander J.G., Tinetti M., Woolard N., Studenski S., High K. and Asthana S.) 6th edition. McGraw-Hill, New York, NY.

Aviv A., Gardner S., Kuchel G.A., Kummerfeld S., Love C.L., Vlassara H., White M. and Colins A. (2008) Inflammation’s Effects on Aging IN The Future of the Human Healthspan. Demography, Evolution, Medicine and Bioengineering. Task Group Summaries. The National Academies. Keck Futures Initiative. The National Academies Press. Washington, DC.

DuBeau C.E., Harari D., Johnson T., Kuchel G.A., Palmer M., Pfisterer M. and Wagg A. (2008) Incontinence in The Frail Elderly. IN Incontinence.  4th International Consultation on Incontinence. July 4-7, 2008. Editions 21, Paris, France

Kuchel G.A. and DuBeau C.E..(2009)  Urinary Incontinence in the Elderly. Ch. 27. IN Geriatric Nephrology Curriculum.  (Eds.  Kohan D. and Oreopoulos D.), American Society of Nephrology

Smith P.P. and Kuchel G.A. (2010) Aging of the Urinary Tract. Ch.18, Pgs. 111-116.  IN Brocklehurst's Textbook of Geriatric Medicine and Gerontology. (Eds. Fillit H.M., Rockwood K. and Woodhouse K.) 7th edition. Elsevier, Philadelphia, PA.

Kuchel G.A. (2010) Question Contributor for Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine. Pacala JT, Sullivan GM, eds. 7th Ed. New York, NY: American Geriatrics Society.

Kuchel G.A. (2010) Aging versus Disease. Ch.2, Pgs. 8-13  IN Cutting Edge. Ageing and the Lower Urinary Tract. Astellas Pharma, A/S Denmark.

Kuchel G.A. (2011) Question Contributor for Geriatrics Nursing Review Syllabus: A Core Curriculum in Advanced Practice Geriatric Nursing. Flaherty E, Resnick B. eds. 3rd Ed. New York, NY: American Geriatrics Society. 

DeAngelis A., Smith P.P. and Kuchel G.A. (2012) MIF and Lower Urinary Tract Disorders.   Chapter III-5, Pgs. 257-275 IN The MIF Handbook. (Ed. Bucala R.) World Scientific Publishing, Hackensack, NJ.

Kuchel G.A., Robison J. and Fortinsky R. (2012) Physiological, Psychological and Social Aspects of Aging. Ch. 3, Pgs. 35-51 IN Cancer and Aging handbook: Research and Practice. (Eds. Bellizzi K. and Gosney M.), Wiley-Blackwell, Hoboken, NJ.

Current Grants
U13AG039151                                     Kuchel (PI)                                       7/1/2012-6/30/2015
AGS/NIA Conference Series in Geriatrics: From Bedside to Bench
Role: PI

P01 AG021600                                    Haynes (PI)                                      7/1/2012-6/30/2015
NIH/NIA
Aging and Immunity to Infection
Role: Project and Site PI

P01 AG031720                                    Inouye (PI)                                       4/15/2010-3/31/2015      
NIH/NIA
Harvard Interdisciplinary Study of Delirium and Its Long-Term Outcomes - Biomarker Discovery for Delirium.
Role: Co-Investigator

R01AG022092                                     White/Wolfson (co-PIs)                 9/15/2011-8/31/2016
NIH/NIA
Intensive Blood Pressure Reduction to Lessen Functional Decline
Role: Co-Investigator

No Number                                          Kuchel (PI)                                      7/1/2012-6/30/2014
Connecticut State Stem Cell Research Program;
Embryonic and pluripotent stem cell-produced factors as novel therapeutic candidates for improving muscle function and regenerative responses in humans.uality Predictors of Sarcopenia, Physical Performance and Frailty in Older Adults
Role: Role: PI

NSF 13-500                                        Pattipati (PI)                                     10/1/2013-9/13/2016
National Science Foundation                           
CyberSEES: Type 2: Fault Detection, Diagnosis and Prognosis of HVAC systems
Role: Co-Investigator

Research Staff
Xin Zhou, PhD
Qing Zhu, M.D., M.Sc.

Educational Contribution
Students (MD)
Fellows (MD)
Residents (MD)
CME

Contact Information
Phone: 860-679-3956
Fax: 860-679-1307

  
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