George Kuchel, M.D., F.R.C.P.
Professor of Medicine
Citicorp Chair in Geriatrics and Gerontology
Director, UConn Center on Aging
Chief, Division of Geriatric Medicine
McGill University (MD CM) 1980
McGill University, Montreal General Hospital, Internal Medicine 1982-1985
Harvard Medical School, Geriatric Medicine 1985-1988
1. Pathophysiology of common geriatrics syndromes
2. Role of inflammatory molecules in mediating the loss of muscle and neural elements shown to contribute to detrusor underactivity and sarcopenia in frail older adults
3. Design and validation of pleiotropic and targeted interventions capable of altering the natural history of common geriatrics syndromes.
Areas of Special Clinical Interest
Geriatric Assessment, Urinary Incontinence
French, Czech, Slovak, Hungarian
Cai W., Uribarri J., Zhu L., Chen X., Swamy S., Zhengshan Z., Grossjean F. Simonara C., Kuchel G.A., Schnaider-Beeri M., Woodward M., Striker G.E. and Vlassara H. (2014) Oral Glycotoxins are a Modifiable Cause of Dementia and the Metabolic Syndrome in Mice and in Humans. Proceedings of the National Academy of Sciences (USA) Apr 1;111(13):4940-5. doi: 10.1073/pnas.1316013111. Epub 2014 Feb 24. PMID: 24567379
Wagg A., Gibson W., Johnson T. 3rd, Markland A., Palmer M.H., Kuchel G.A., Szonyi G., and Kirschner-Hermanns R. (2014) Urinary incontinence in frail elderly persons: Report from the 5th International Consultation on Incontinence. Neurourology Urodynamics. Apr 2. doi: 10.1002/nau.22602. [Epub ahead of print] PMID:24700771
Chirch L.M., Hasham M., and Kuchel G.A. (2014) HIV and aging: A clinical journey from Koch’s Postulate to the chronic disease and geriatric syndrome model Current Opinion in HIV and AIDS Jul;9(4):405-11. doi: 10.1097/COH.0000000000000074. PMID:24824883 [PubMed - in process]
Wang Y., Eliot M., Kuchel G.A., Schwartz J., Coull B.A., Mittleman M.A., Lipsitz L.A. and Wellenius G.A. (2014) Long-term Exposure to Ambient Air Pollution and Serum Leptin in Older Adults: Results from the MOBILIZE Boston Study Journal of Occupational and Environmental Medicine Sep;56(9):e73-e77. PMID: 25192230 [PubMed - as supplied by publisher]
Kositsawat J., Kuchel G.A., Tooze J.A., Houston D., Cauley J.A., Kritchevsky S.B., Strotmeyer E.S., Kanaya A.M., Harris T.B., Johnson K.C. and Barry L.C. (2014) Vitamin D Insufficiency and Abnormal Hemoglobin A1c in Black and White Older Persons. Journal of Gerontology: Medical Sciences Aug 11. pii: glu122. [Epub ahead of print] PMID: 25112493 [PubMed - as supplied by publisher]
Wolff G., Kuchel G.A. and Smith, P.P. (2014) Overactive bladder in the vulnerable elderly. Research and Reports in Urology. Oct 3;6:131-8. doi: 10.2147/RRU.S41843. PMID: 25328867 [PubMed]
Dill J., Unson C., Kenyon-Pesce L., Kuchel G.A. and McElhaney J. (2014) Recruitment and Retention of Healthy and High-Risk Older Adults for a Multi-Year Influenza Vaccination Trial. Connecticut Medicine 78(8):481-486. PMID:25314888 [PubMed - in process]
Tyagi P., Smith P.P., Kuchel G.A., deGroat W.C. , Birder L.A., Chermansky C.J., Adam R.A., Tse V., Chancellor M.B. and Yoshimura N. (2014) Pathophysiology and Animal Modeling of Underactive Bladder International Urology and Nephrology 46 (Suppl 1):S11–S21. doi: 10.1007/s11255-014-0808-9. Epub 2014 Sep 20. PMID: 25238890
Griebling T., DuBeau C., Kuchel G., Wilde M.H., Lajiness M., Tomoe H., Diokno A., Vereecke A. (2014) Defining and advancing education and conservative therapies of underactive bladder International Urology and Nephrology 46 (Suppl 1):S29–S34, DOI 10.1007/s11255-014-0799-6, Sep 20. PMID: 25238892
Smith P.P., Tyagi P., Kuchel G.A., Pore S., Chermansky C., Chancellor M., Yoshimura N. and Levanovich P. (2014) Advanced Therapeutic Directions to Treat the Underactive Bladder International Urology and Nephrology 46 (Suppl 1):S35–S44, DOI 10.1007/s11255-014-0809-8, Sep 20. PMID: 25238893
Fragala M., Kenny A.M. and Kuchel G.A. (2015) Muscle Quality and Aging: A Multidimensional Approach to Muscle Functioning with Applications for Treatment. Sports Medicine May;45(5):641-58. doi: 10.1007/s40279-015-0305-z. PMID:25655372
AGS/NIA Writing Group on Delirium in Older Adults. AGS/NIA Bench-to-Bedside Conference: Research Agenda on Delirium in Older Adults (2015) Journal of the American Geriatrics Society May;63(5):843-52. doi: 10.1111/jgs.13406. Epub 2015 Mar 31. No abstract available. PMID:25834932 [PubMed - indexed for MEDLINE]
Kim J., Carlson M.E., Kuchel G.A., Newman J.W. and Watkins B.A. (2015) Dietary DHA reduced downstream endocannabinoid and inflammatory gene expression, epididymal fat mass and improved aspects of glucose use in muscle in C57/blk6 mice International Journal of Obesity Jul 29. doi: 10.1038/ijo.2015.135. [Epub ahead of print] PMID: 26219414 [PubMed - as supplied by publisher]
Smith P.P. and Kuchel G.A. (2015) Clinical Meaning of an Elevated Post-Void Residual: When the value of a result is both less and more than one would expect Journal of the American Geriatrics SocietyJul;63(7):1432-4. doi: 10.1111/jgs.13479. PMID:26189846
Vasunilashorn S., Ngo L., Inouye S.K., Libermann T.A., Jones R.N., Alsop D.C., Guess J., Jastzebski S., McElhaney J.E., Kuchel G.A.* and Marcantonio E.R.* (2015) Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery. Journal of Gerontology: Medical Sciences Oct;70(10):1289-95. doi: 10.1093/gerona/glv083. Epub 2015 Jul 27. pii: glv083. [Epub ahead of print] PMID:26215633 *co-last authors
Smith P.P., Kuchel G.A. and Griffiths D. (2015) Functional Brain Imaging and the Neural Basis for Voiding Dysfunction in Older Adults. Clinics in Geriatric MedicineNov;31(4):549-565. doi: 10.1016/j.cger.2015.06.010. Epub 2015 Aug 18.
Smith P.P., Gallfy A., Pregenzer G. and Kuchel G.A. (2015) Underactive Bladder and Detrusor Underactivity Represent Different Facets of Volume Hyposensitivity and not Impaired Contractility Bladder Vol. 2(2) | e17, DOI: 10.14440/bladder.2015.60
Ble A., Masoli J., Barry H.E., Winder R.E., Tavakoly B., Henley W.E., Kuchel G.A., Valderas J.M., Melzer D. and Richards S.H. (2015) Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. BMC Geriatrics Nov 5;15:146. doi: 10.1186/s12877-015-0143-8. PMID: 26542116 [PubMed - in process]
Schmitt E.M., Saczynski J.S., Kosar C.M., Jones R.N., Alsop D.C., Fong T.G., Metzger E., Cooper Z., Marcantonio E.R., Travison T., Inouye S.K. and the Successful Aging After Elective Surgery Study Group. The Successful Aging After Elective Surgery Study: Cohort Description and Data Quality Procedures. Journal of the American Geriatrics Society 2015 Dec 14. doi: 10.1111/jgs.13793. [Epub ahead of print]PMID:26662213 [PubMed - as supplied by publisher]
The CSR Study Section Perspective. Getting to Know the National Institute on Aging. A Symposium for Go-Getters in Aging Research. Annual Meeting of the American Geriatrics Society, Washington, DC, 05/15/2015.
What Should be the Role of Geriatricians in the Geroscience Initiative: Leaders, Collaborators, Consultants or Observers? Organizer and Speaker, Annual Meeting of the American Geriatrics Society, Washington, DC 05/16/2015.
Urologic Health in Women Research Network Expert Panel. Society for Women’s Health Research. 06/30/2015
NIA Workshop on Measures of Physiologic Resiliencies and Vulnerabilities in Human Aging, Program Co-Chair with Dr Anne Newman, Bethesda, MD, 08/26-27/2015
Best Practice Recommendations for Management of Overactive Bladder in the Elderly. Invited Speaker. Annual Meeting of the Gerontological Advances Nurses Practice Association. San Antonio, TX, 10/3/2015.
Systems-Based Pathophysiology of Voiding Disorders in the Elderly: What Can Urologists. Geriatricians and Cell Biologists Learn from Each Other. Grand Rounds. Department of Urology, University of Texas Southwestern, Dallas, 10/21/2015.
A Geriatrician’s Approach to Managing Voiding Disorders in the Elderly. Grand Rounds. Division of Geriatric Medicine, University of Texas Southwestern, Dallas, 10/21/2015.
AGS/NIA Bedside to Bench Conference in Geriatrics. Delirium in Older Adults: Finding Order in the Disorder. 02/09/2014-02/11/2014 (Conference Series Organizer and Chair)
Keynote Lecture: Where are we today with the aging underactive bladder. First International Congress of Urologic Research and Education on Aging Underactive Bladder (CURE-UAB), Bethesda, MD, 02/20-21/2014.
Muscle Quality in Regenerative Capacity in Sarcopenia and Frailty. 35th Annual General Meeting of the Canadian Geriatric Society. Montreal, Quebec. 04/17/2015.
Frailty Phenotype is Associated with Declines in Muscle Mass, Performance, Quality and Integrity with Suggestion of Compensatory Hypertrophy. International Conference on Frailty and Sarcopenia Research. Boston, MA 4/24/2015.
AGS/NIA Bedside to Bench Conference in Geriatrics. Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning. 10/04/2015-10/06/2015. (Conference Series Organizer and Chair)
NIA/NIH; Immune Response to High-Dose vs. Standard Dose Influenza Vaccine
R01AG048023; George Kuchel, MD (communicating PI) and Janet McElhaney (PI)
Total Budget: $1,934,901; 7/15/14-5/31/19
This 5-year proposal is a randomized study of split-virus influenza vaccine (SVV) in a high-dose (HD) vs. standard dose (SD) formulation in each of five influenza seasons to define the key determinants of vaccine-mediated protection against influenza and how these immunologic mediators may be enhanced by vaccination with a newly approved high-dose influenza vaccine in frail older subjects.
Role: PI (Multiple PI Grant)
NIA/NIH; Aging and Immunity to Infections
P01AG021600; Laura Haynes, PI
George Kuchel, MD (co-investigator – 10% effort and Project PI)
Total Budget: $7,665,668; Project 4 Budget: $1,711,028; $261,090 direct/yr; 9/15/13-5/31/17
The goal of this award is to understand how aging affects the immune system and the capacity of older adults to respond to influenza vaccine. The focus of the studies conducted at UCHC will be elucidate the nature of the defects in the generation of effector and memory functions in aged naïve CD4+ T cells and determine their potential reversibility in cells from older adults using vaccines and adjuvants.
Role: Project 4 PI
NIA/NIH; AGS/NIA Bench to Bedside Conference Series in Geriatrics
U13AG039151; George Kuchel, PI
Total Award: $ 150,000; 7/1/12-6/30/16
The goal of this U13 Conference Grant application is to fund a series of three annual conferences addressing new research approaches into Delirium, Sleep Disorders and Urinary Incontinence, with an emphasis on shared risk factors and bidirectional relationships between these common geriatric syndromes.
Pending Grant Support:
NIAID; Genomics and Epigenomics of the Elderly Response to Pneumococcal Vaccines.
R01 AG052608; Jacques Banchereau (PI) Jackson Laboratory for Genomic Medicine, Farmington, CT
Budget: $1,580,481; 4/01/16-3/31/20
Aging-associated declines in the ability to combat infection represent a major threat to the health, independence and survival of older adults. In this study we will probe the aged immune system in the context of pneumococcal vaccination since even within the landscape of broad late-life vulnerability to infectious and chronic diseases, pneumonia due to Streptococcus pneumoniae infection assumes an overwhelmingly important role; as the leading cause of community-acquired and in-hospital pneumonia in the US and globally, and a major cause of morbidity and mortality in the elderly. The two approved pneumococcal vaccines, PPSV23 (Pneumovax®) and PCV13 (Prevnar®), display some efficacy, particularly in young adults; however, their efficacy in the elderly is limited. This study will evaluate the impact of aging on genomic and epigenomic responses within peripheral white blood cells upon administration of these vaccines.
Role: Co-Investigator (10% effort)
Recently Completed Grant Support:
NIA; Harvard Interdisciplinary Study of Delirium and its Long-Term Outcomes.
P01 AG031720; Sharon Inouye, PI (Harvard/Beth Israel); George Kuchel, co-inv: 2% effort. Total Award: $9,134,878; 04/15/10-03/15/15
The goal of the UConn component of this P0-1 Program Project is to obtain a cytokine “signature” for post-operative delirium by performing multiplex cytokine measurements in older subjects undergoing scheduled cardiac and orthopedic surgery.
Connecticut State Stem Cell Research Program;
12-SCA-UCHC-15 Embryonic and pluripotent stem cell-produced factors as novel therapeutic candidates for improving muscle function and regenerative responses in humans.
George Kuchel, MD - PI
Morgan Carlson, PhD (co-investigator)
Total Budget: $200,000 (7/1/12-2/29/16; no cost extension)
The goal of this project is to define the pro-regenerative factors produced by embryonic and induced pluripotent stem cells which have the potential to positively regulate the behavior of young and old muscle stem (satellite) cells, offering the potential for the “youthful” reprogramming of aged stem cells and for interventions targeting sarcopenia and functional declines in old age.
National Science Foundation
NSF 13-500; CCF-1331850;CyberSEES: Type 2: Fault Detection, Diagnosis and Prognosis of HVAC systems
Krishna R. Pattipati, PI
Total Budget: $1,090,000; 10/1/13-9/30/16
Heating, Ventilation and Air Conditioning (HVAC) constitutes 57% of energy used in commercial and residential buildings, valued at $223B in 2009. This proposal seeks to develop Fault Detection, Diagnosis and Prognosis (FDDP) methodologies for HVACs to improve equipment availability, lower energy and operating costs, extend equipment life, and enhance occupants’ comfort in retirement communities, taking into account physiological changes, psychological factors and personal preferences.
HRSA; Geriatric Outreach and Training with Care (GOT Care!)
UD7HP26898; Millicent Malcolm, PI (UConn School of Nursing)
Total Budget: $1,401,225; 7/1/14-6/30/17
The goal of this award is to create opportunities for team-based education and clinical collaboration in Geriatrics involving a diverse pool of undergraduate/pre-licensure and advanced practice graduate students with inter-professional faculty and students/residents from the disciplines of medicine, dental medicine, pharmacy, physical therapy, social work, and public health. The project will also improve access and coordination of care for the vulnerable geriatric population in the Middlesex County, CT, service area.
UCHC-UConn Storrs Seed Grant Funding in Cancer Control
Exercise, Bone and Cardiovascular Health in Breast Cancer Survivors
Co-PIs: Keith Bellizzi (Storrs) and Pam Taxel (UCHC)
Total Budget: $35,000; 07/1/14-06/30/15
The goal of this pilot study is to recruit 50 postmenopausal women with hormone-receptor positive tumors who have received primary treatment for localized breast cancer (including any combination of surgery, chemotherapy or radiation therapy) and currently scheduled to receive adjuvant AI therapy. Participants will be randomly assigned to a 6 month resistance exercise intervention or a usual care group. Measures of bone, muscle health and cardiovascular health plus HRQOL will be assessed in both groups at baseline, three months, and six months. The study’s primary goal is to gather preliminary data on the efficacy of a six month exercise intervention program to reduce adverse complications from the use of AIs in postmenopausal breast cancer survivors.
Pending Grant Support:
PCORI-PFA-2015-Spring (Fortinsky) 11/01/15-10/31/20 0.60 cal mos (yr 1)
Patient Centered Outcomes Research Institute (PCORI) $6,204,645 0.36 cal mos (yrs 2-5)
3D Team Care for Cognitively Vulnerable Older Adults
This research will compare two clinical interventions, feature outcomes of importance to patients and family caregivers, be powered to detect clinically meaningful effects, and engage patient, family, and other relevant stakeholders in study execution and results dissemination.
Study sections with NIH
Member, Special Emphasis Panel, ZAG1 ZIJ - 7 (O2) The LIFE Outcomes Study (LIFE-OS) 06/27/14
Chair, Monitoring Board, NIA/NIH Longevity Consortium Translational Research Core; U19AG23122; PI: Steven Cummings, MD; 2013-
Member, Special Emphasis Panel, ZAG1 ZIJ-3(J4) Treatments of Aging Obese Patients; 11/06/14
Chair, Special Emphasis Panel, ZAG1 ZIJ-7(J2) Cerebrovascular Disease and Aging; 11/10/14
Chair, Special Emphasis Panel, ZAG1 ZIJ-3(M1) GEMSSTAR (Grants for Early Medical/Surgical Specialists' Transition to Aging Research); 2/23/15
Member, Medical Student Training in Aging Research Program (MSTAR) Review Panel, American Federation for Aging Research, 3/17/2015
Xin Zhou, PhD
Editorial Board, Connecticut Medicine, 2007-
Reviewing Board Member, UpToDate Inc., Wolters Kluwer Health, 2013-
Member, Search Committee for Chair of Department of Neurology, UConn & Hartford Hospital, 2015-
Member, Search Committee for Dean of the School of Medicine, UConn, 2015
Chair, Dean’s Task Force on School of Medicine Bylaws, UCHC, 2015
Chair, Search Committee for Chief of the Division of Nephrology, UCHC, 2015
Lee E.C.-H, Rogina B., Haynes L., Kuchel G.A. (2015) Animal Models for Aging, IN Reference Module in Biomedical Sciences. Elsevier. 17-Oct-2014 doi:10.1016/B978-0-12-801238-3.03853-8.
Smith P.P. and Kuchel G.A. (In Press) Aging of the Urinary Tract. Ch.18 IN Brocklehurst's Textbook of Geriatric Medicine and Gerontology. (Eds. Fillit H.M., Rockwood K. and Woodhouse K.) 8th edition. Elsevier, Philadelphia, PA.
Kuchel G.A.. (In Press) Aging and Homeostatic Regulation. IN Hazzard’s Principles of Geriatric Medicine and Gerontology. (Eds. Halter J.B., Hazzard W., Ouslander J.G., Tinetti M., Woolard N., Studenski S., High K. and Asthana S.) 7h edition. McGraw-Hill, New York, NY.
Yap V., Kuchel G.A. and Foley R.J. (In Press) Geriatric Pulmonary Hypertension: Recent Epidemiologic Trends and Treatment Update IN Lung Diseases and Aging: Pulmonary Hypertension(Eds. Lee P. and Bucala R., World Scientific Press, Singapore)