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UConn AgingNet Faculty

George Kuchel, M.D., F.R.C.P.photo of george kuchel, m.d., f.r.c.p.

Academic Title
Professor of Medicine
Travelers Chair in Geriatrics and Gerontology
Director, UConn Center on Aging
Chief, Division of Geriatric Medicine

Education
McGill University (MD CM) 1980

Training
McGill University, Montreal General Hospital, Internal Medicine 1982-1985
Harvard Medical School, Geriatric Medicine 1985-1988

Research Interests
1.        Pathophysiology of common geriatrics syndromes
2.        Role of inflammatory molecules in mediating the loss of muscle and neural elements shown to contribute to detrusor underactivity and sarcopenia in frail older adults
3.        Design and validation of pleiotropic and targeted interventions capable of altering the natural history of common geriatrics syndromes.

Areas of Special Clinical Interest
Geriatric Assessment, Urinary Incontinence

Languages Spoken
French, Czech, Slovak, Hungarian

Selected Publications

Taylor J.A., and Kuchel G.A.. (2006). Detrusor Underactivity: Clinical Features and Pathogenesis of an Underdiagnosed Geriatric Condition. Journal of the American Geriatrics Society  54 (12) 1920-1932.

Taylor J.A., Zhu Q., Irwin B., Maghayadah Y., Tsimikas J., Pilbeam C., Leng L., Bucala R. and Kuchel G.A. (2006) Null mutation in macrophage migration inhibitory factor (MIF) prevents muscle cell loss and fibrosis in partial bladder outlet obstruction. American Journal of Physiology - Renal Physiology  291 (6)  F1343-1353.

Taylor J.A., Kuchel G.A.,  Hegde P., Voznesensky O.S., Claffey K., Tsimikas J., Leng L., Bucala R and Pilbeam C.  (2007) Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice. BMC Cancer 7(1)135-142.  

Pefanco M.A., Kenny, A., Kaplan R, Kuchel G.A., Walsh S., Kleppinger A. and Prestwood K.  (2007) The Effect of 3-year treatment with 0.25 mg/d of Micronized 17β-Estradiol on Cognitive Function in Older Postmenopausal Women.  Journal of the American Geriatrics Society  55 (3) 426-431.

Inouye S.K., Studenski S., Tinetti M.E. and Kuchel G.A. (2007) Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept.  Journal of the American Geriatrics Society  55(5) 780-791 (with accompanying editorial by W.B. Hazzard, MD 55(5) 794-796)

Estrada M., Kleppinger A., Judge J.O., Walsh S.J and Kuchel G.A.(2007) Functional Impact of Relative Versus Absolute Sarcopenia in Healthy Older Women. Journal of the American Geriatrics Society 55(11)1712-1719.

Rudolph J.L., Ramlawi B., Kuchel G.A., McElhaney J.E., Xie D., Selke F.W., Levkoff S.E. and Marcantonio E.R.  (2008) Chemokines are Associated with Delirium after Cardiac Surgery.  Journal of Gerontology: Medical Sciences 63(2):184-9

Leng S.X., McElhaney J.E., Walston J.D., Xie D., Fedarko N.S. and Kuchel G.A. (2008)  ELISA and Multiplex Technologies for Cytokine Measurement in Inflammation and Aging Research. Journal of Gerontology: Medical Sciences  (In Press)

Kuchel G.A. (2008) Using Caveolin-1 Knockout Mouse to Study Impaired Detrusor Contractility and Disrupted Muscarinic Activity in the Aging Bladder. Urology (In Press)

Plotnikov SV, Kenny A, Walsh SJ, Zubrowski B, Joseph C, Scranton VL. Kuchel GA., Dauser D, Xu M, Pilbeam C, Adams D, Dougherty R, Campagnola PJ and Mohler W.A. (2008)  Measurement of muscle disease by quantitative second-harmonic generation imaging. Journal of Biomedical Optics  (In Press)

Current Grants
R01 AG028657; Role PI; 4/1/2007-3/31/2012 
NIH/NIA; Pathogenesis of detrusor underactivity and urinary retention in the frail elderly.
$1,517,000

R01 AR54713; Role co-PI (PI: DW Rowe) 7/1/2006-6/30/2011 
NIH/NIAMS. Assessing Lineage Decisions of Musculoskeletal Progenitor Cells with Aging 
$1,953,600 

R01 AI068265; Role co-PI (PI: JE McElhaney) 4/1/2005-3/31/2010
NIH/NIAID. T-Cell Responses Predict Influenza Risk in Older Adults 
$2,093,690

American Geriatrics Society; Role co-PI with K Parham 7/1/2007-6/30/2009
Geriatrics for Specialists Award
$40,000

Research Staff
Dan Sasso, B.Sc.
Qing Zhu, M.D., M.Sc.

Educational Contribution
Students (MD)
Fellows (MD)
Residents (MD)
CME

Contact Information
Phone: 860-679-3956
Fax: 860-679-1307

Personal Links
Click Here For URL #1
Click Here For URL #2

  
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